Mlb Schedule 2025 Opening Day 2025. The 2025 mlb opening day schedule gets going as the orioles host the angels at 3:05 p.m. The official opening day in mlb is scheduled for thursday, march 28, when all 30 teams are scheduled to play.
Here’s a look at the 15 opening day matchups in 2025 (all start times tbd): Before the 2023 season, the last time every team played on.